Manufacturing

Articles

Michigan State University researchers have discovered a technique for viewing whole cells to gain an understanding of protein inclusion bodies.

NMR Approach May Speed Up Protein-Based Drug Development

The authors describe a novel analytical approach that uses the shape-analysis capabilities of MFI to detect and enumerate silicone oil microdroplets in protein formulations that also contain aggregates of similar size and in a similar concentration.

Silicone Microdroplets in Protein Formulations—Detection and Enumeration

Michelle Hoffman, editorial director of Pharmaceutical Technology.

Molecules called "chaperones" facilitate correct protein folding.

Coming Down the Pike: Chaperones

Drugmakers seeking to block the activity of a protein may have a new strategy at their disposal.

Coming Down the Pike: Protein-Substrate Binding

Polyplus-transfection, a company that researches, develops, and commercializes drug-delivery solutions for biomolecules, created a new technology designed to enhance in vivo delivery of small interfering RNAs (siRNAs) when they are associated with a cationic polymer.

Technology Designed to Improve siRNA Delivery

What makes a drug ripe for respiratory delivery?

Journey to the Center of the Lung

Scientists at The Wistar Institute are taking further steps into understanding a gene regulator that can lead them closer to developing new cancer therapies.

Gene Regulator Key to New Cancer Therapies

An updated book summarizes recent research for formulators and drug-delivery specialists.

Designing and Delivering Therapeutic Proteins

Ian Sellick is marketing director at Pall Corporation.

One of the greatest challenges facing biopharmaceutical manufacturers has been the primary recovery of recombinant materials from transgenic sources. As an alternative to existing methods, vibrating membrane technology, which is widely used in food and beverage processing, recently has been adapted to biopharmaceutical applications involving transgenic biosolutions.

Manufacturing, Expression Systems