Dosage Forms

Articles

The authors describe the various available technologies used in orally disintegrating tablets.

Orally Disintegrating Tablets: The Effect of Recent FDA Guidance on ODT Technologies and Applications

NIR Prediction of Solid Dosage Form Dissolution Profiles - Foss Whitepaper

Extending Calibrations for Near-Infrared Assay of Tablets Using Synthetic Modeling and Variance from Placebos - Foss Whitepaper

The authors prepared granules containing cinnarizine using polyethylene glycol 6000 as a melting binder and lactose monohydrate as hydrophilic filler. The effects of binder concentration and size were studied.

Formulation and Process Optimization of Cinnarizine Fast-Release Tablets

Bulk Inspection of Tablets-Symetix Applicaton Note

Jason Hansell is Junior Applications Technologist at Colorcon Inc. (PA, USA).

Ngoc Do is Senior Technical Manager Film Coatings & Excipients at Colorcon Inc. (PA, USA).

Thomas P. Farrell is Global Director, Immediate Release Technologies, at Colorcon Inc. (PA, USA).

Based on formulation simplicity and blinding capability, hard gelatin capsules are preferrable compared with other oral solid dosage forms, including tablets, in the early clinical phases of drug development.

Narrowing the gap between clinical capsule formulations and commercial film-coated tablets

Pradeep Karatgil is from Custom Pharmaceutical Services, Dr Reddy's Laboratories Ltd (India).

Raviraj Pillai is Vice President, Integrated Product Development, at Dr Reddy's Laboratories Ltd (India). ravip@drreddys.com

Orally disintegrating tablets offer numerous advantages compared with traditional tablets and capsules, and can be an effective solution for developing line extensions of currently marketed therapies.

Orally disintegrating tablets: the path to improved patient compliance and enhanced life cycle management

Bulk Inspection of Tablets-Symetix Application Note

The authors examine common superdisintegrants (i.e., crospovidone Type A, crospovidone Type B, croscarmellose sodium, and sodium starch glycolate) with a set of poorly soluble drug actives and evaluate in vitro drug dissolution.

Influence of Superdisintegrants on the Rate of Drug Dissolution from Oral Solid Dosage Forms

The authors extend the range of a near-infrared calibration model for tablet assay using production 'seed' spectra and synthetic spectra generated from placebos and 'pure' active pharmaceutical ingredient spectra.

Solid/Semi-Solid Dosage