Dosage Forms

Articles

During the past years, there has been increasing demand for fast dissolving disintegrating tablets (FDDTs), such as orally disintegrating tablets (ODTs) and sublinguals.

Fast dissolving disintegrating tablets with isomalt

A new excipient for orally disintegrating tablets not only imparts superior tablet characteristics, but has the added advantage of allowing users to maintain full control over their formulations, manufacturing processes and intellectual property.

Application-related properties of a new fast dispersible excipient

Angie Drakulich was editorial director of Pharmaceutical Technology.

A US Food and Drug Administration guidance issued Tuesday provides new recommendations to applicants who wish to designate proposed products as orally disintegrating tablets (ODTs).

Guidance for Orally Disintegrating Tablets Issued

Jim Miller is president of PharmSource Information Services, Inc., and publisher of Bio/Pharmaceutical Outsourcing Report.

Despite challenges, contract manufacturers in Europe are enjoying considerable success.

Leading European CMOs Consolidate Market Positions

Research shows that both drug prescription and alcohol consumption increase within the elderly population. It is, therefore, necessary to fully understand the impact of alcohol consumption on solid oral dosage forms, especially extended release formulations.

The influence of concomitant use of alcoholic beverages on hypromellose matrix tablets

Patricia Van Arnum was executive editor of Pharmaceutical Technology.

Optimizing the solid form of a drug reaps scientific and technical awards.

Exploring Solid-State Chemistry

S. Gebert is a pharmaceutical engineer, BASF

K. Meyer-Böhm is a research and development (R&D) manager, BASF

K. Kolter, PhD, is head of R&D for pharmaceutical excipients, BASF SE, G-EMP-MD-H201, Ludwigshafen, Germany, 67056, tel. + 49 621 6041664, fax; 49 621 6097370, karl.kolter@basf.com

The authors examine the effectiveness of an excipient comprised of mannitol, polyvinyl acetate, and crospovidone using model actives loperamide hydrogen chloride and caffeine.

Development of Orally Disintegrating Tablets Based on a New Excipient

Charlie Martin is a general manager at Leistritz North America

The author describes the benefits, processes, and practicality of using hot-melt extrusion to mix active pharmaceutical ingredients with pharmaceutical-grade polymers.

Continuous Mixing of Solid Dosage Forms via Hot-Melt Extrusion

The use of PVA copolymer-based film can solve the problems associated with lack of film adhesion... to tablets containing large amounts of waxy excipient or a lubricant.

Solid/Semi-Solid Dosage