Dosage Forms

Articles

USP announced an interim revision to its monograph for levothyroxine sodium tablets, which will become official in USP 32-NF 27.

USP Revises Potency Spec for Levothyroxine Sodium Tablets

Stephen H. Wu, PhD, is a technical fellow in the Pharmaceutical R&D division of Mallinckrodt PharmaceuticalâCovidien Ltd.

The authors propose an alternative to the USP disintegration test method. The method embraces physiological conditions of the oral cavity, as a screening tool for developing ODT products.

An Alternative to the USP Disintegration Test for Orally Disintegrating Tablets

Patricia Van Arnum was executive editor of Pharmaceutical Technology.

3M Drug Delivery Systems has successfully designed a proof of concept device using a solid microstructured transdermal system for the systemic delivery of high-potency pharmaceuticals. The technology was showcased at a poster session at the annual meeting of the Controlled Release Society held this week in New York City.

Solid Microstructured Transdermal Delivery Highlighted at Controlled Release Society's Meeting

The authors demonstrate that anecdotal reports of prednisone tablet variability are inaccurate.

Variability of USP Lot P Prednisone Reference Standard Tablets

When drugs are encapsulated, electrification (the electrostatic charge of the capsule) may sometimes cause problems, such as capsule adhesion during transportation or dispersion of the capsule content in the filling process.

Creating PVA copolymer capsules

Recent advances in SEM, particularly the incorporation of automation and software, have made simpler, lower-end SEM instruments easy to operate and have improved the capabilities of larger, sophisticated instruments.

Developments in Scanning Electron Microscopy for Tablet and Granule Characterization

Traditional tablet presses do not measure tablets' tensile strength, yet this characteristic strongly influences tablet quality. The author describes a compression technique that accounts for tensile strength and produces tablets with consistent weight and disintegration time.

Improving Tablet Quality with Compression to Equal Force Technology

Spraying techniques can be used to produce powder form formulations. The concept works by the adsorption/absorption of a liquid SELF onto a neutral carrierâ€¦

Solid dosage forms from self-emulsifying lipidic formulations

Chemical imaging of solid dosage forms has become a powerful analytical tool for the development of solid dosage forms.

New Dimensions in Tablet Imaging

To ensure an effective treatment, a patient often must take equal doses of an active pharmaceutical ingredient (API) at regular intervals.

Solid/Semi-Solid Dosage