Dosage Forms

Articles

In the manufacture of many pharmaceutical products, dry-particle blending is a critical step that directly affects content uniformity.

Scale Up of Powder-Blending Operations

Extrusion-spheronization and pellet compression are effective means of developing first-order kinetic, controlled-release drug delivery systems of azithromycin (AZI). The authors prepared, evaluated, and optimized AZI formulations and assessed the stability of the selected formulation under accelerated storage conditions.

Using Extrusion-Spheronization to Develop Controlled-Release Formulations of Azithromycin

Pharmaceutical Science & Technology Innovations

In the Spotlight-February 2005

Laser-Marking Technique Improves Tablet Branding

Albumin-Bound Nanoparticle Drug Nabs FDA Approval

The author reviews the effects of moisture on flow properties, tensile strength, Heckel plot, energies involved in compaction, and elastic recovery.

An Overview of the Effect of Moisture on Compaction and Compression

From solving complex formulation challenges to delivering full product-development programs, outsourcing services organizations provide valuable expertise, experience, and technical know-how.

The Outsourcing Advantages in Formulation Development

Adel M. Aly, PhD, is an associate professor of industrial pharmacy.

The authors examine the effects of three superdisintegrants on the dissolution and absorption of tenoxicam from solid-dispersion formulations.

Superdisintegrants for Solid Dispersion To Produce Rapidly Disintegrating Tenoxicam Tablets via Camphor Sublimation

Microspheres of Eudragit RL were developed for colonic delivery of albendazole. The effects of polymer concentration, stirring rate, and concentration of emulsifier on particle size and drug loading were studied. A comparative in vitro drug release study of the optimized formulation was carried out.

The Preparation and Evaluation of Albendazole Microspheres for Colonic Delivery

Size reduction of materials through comminution is employed in many industries, including agrochemicals, minerals, ceramics and pharmaceuticals. The reasons for particle size reduction depend on the industry in question. Within the pharmaceutical industry, a large percentage of products are formed from powders and undergo processing to improve dosage form properties. Particle size reduction prior to compacting to tablets can aid with dissolution and homogeneity. Such processing of powders is, in part, dependent on their mechanical properties and balancing these properties is crucial in achieving desired manufacturing performance. Generally, pilot-scale milling trials are run to determine the most effective and efficient mill and operating conditions for each material. These trials, however, require relatively large quantities of material as well as time, and are normally run in early development when sufficient material becomes available. Hence, it would be highly beneficial to identify a physical property..

Solid/Semi-Solid Dosage