Dosage Forms

Articles

With creative engineering and sophisticated chemistry, industry scientists offer big solutions for attaining small particle sizes and narrow distributions.

Bringing Formulations to Size: Strategies for Micro- and Nanoparticle Development

Freeze pelletization is a new and simple technique for producing spherical pellets for pharmaceutical use.

A Novel Freeze Pelletization Technique for Preparing Matix Pellets

Using dimensionless analytical models, the authors establish the relationships among the essential parameters of a kneading complexation process.

Analysis of a Kneading Process to Evaluate Drug Substance-Cyclodextrin Complexation

Excel file and formula for Determining Probability of Passing the USP Content Uniformity Test

The authors suggest a design strategy for an aseptic process simulation that focuses on the basic repeating unit of the process, establishing alert and action criteria for the unit itself, and using worst-case simulations to establish routine operational parameters for the manufacturing process.

Design of an Aseptic Process Simulation

Pramote Cholayudth previously was the managing director of the Professional Conference Center, Ltd. He currently is a validation consultant to Biolab Co., Ltd., in Thailand. He is the founder and manager of PM consult, cpramote2000@yahoo.com.

A straightforward approach reveals how the probability of passing the USP content uniformity test can be calculated for tablets and capsules.

Use of the Bergum Method and MS Excel to Determine the Probability of Passing the USP Content Uniformity Test

Fernando J. Muzzio, PhD, is a professor and the director of the pharmaceutical engineering program at the Department of Chemical and Biochemical Engineering, Rutgers University, 98 Brett Road, Piscataway, NJ 08854-8058, tel. 732.445.3357.

In this final part of a series of three articles, the results from experiments involving cohesive materials are discussed in terms of mixing performance, agglomerate comminution, and lubrication of powder mixtures.

Characterization of the Performance of Bin Blenders-Part 3 of 3: Cohesive Powders

This article reviews various physicochemical approaches that may be employed to enhance absorption following oral administration of solid dosage forms in humans. This article also examines strategies based on capitalizing or neutralizing physiological processes.

Physicochemical Approaches to Enhancing Oral Absorption

A novel probe design can reduce the powder-sample density variance such that moisture and solvent levels can be accurately modeled and predicted in process.

Monitoring Granulation Drying Using Near-Infrared Spectroscopy for In Situ Analysis of Residual Moisture and Methanol

Ranga Velagaleti is the manager of laboratory and stability at BASF Corporation, 8800 Line Ave., Shreveport, LA 71106, tel. 318.861.8040, fax 318.861.8004, velagar1@basf-corp.com

The results of forced degradation studies indicate the need for alternatives to valerophenone as an internal standard calibration for quantifying ibuprofen in bulk drug and tablet assay samples.

Photosensitivity of Internal Standard Valerophenone Used in USP Ibuprofen Bulk Drug and Tablet Assay and Its Effect on the Quantitation of Ibuprofen and Its Impurities

Solid/Semi-Solid Dosage