Dosage Forms

Sanjay Garg is an assistant professor at the National Institute of Pharmaceutical Education and Research (NIPER), Sector 67, S.A.S. Nagar, Punjab­ 160062, India, tel. 91 172 214682; fax 91 172 214692.

Articles

Semisolid dosage forms are advantageous in terms of their easy application, rapid formulation, and ability to topically deliver a wide variety of drug molecules.

Recent Advances in Semisolid Dosage Forms for Dermatological Application

Andrea Leone-Bay is a senior director of project management at Emisphere Technologies, Inc., 765 Old Saw Mill River Road, Tarrytown, NY 10591, tel. 914.785.4733, fax 914.593.8281.

Linda Gerspach is a research associate at Emisphere Technologies, Inc.

Catherina O’Shaughnessy is a senior research associate at Emisphere Technologies, Inc.

Rajesh Agarwal is a director of pharma- ceutics R&D at Emisphere Technologies, Inc.

Connie Rosado-Gray is a project coordinator at Emisphere Technologies, Inc.

Theresa Rivera- Schaub is a project manager at Emisphere Technologies, Inc.

Robert A. Baughman is a senior vice-president of development at Emisphere Technologies, Inc.

The delivery agent-mediated transport of low moleular weight heparin across Caco-2 cells is accomplished without opening the junctions or adversely affecting the structural integrity of the cell monolayer.

Oral Low Molecular Weight Heparin Absorption From Solution and Solid Dosage Forms in Rat, Dog, and Monkey Models

JosÃ© E. MartÃ­nez is a consultant at JEM Consulting Services, Box 4956 PMB 652, Caguas, PR 00726, tel. 787.349.3857.

Low levels of some microorganisms that are present in oral solid dosage forms are unlikely to present a risk to patients. The amount of water activity in these products can help determine when microbiological testing should be conducted.

Microbial Bioburden on Oral Solid Dosage Forms

To achieve the maximum performance from a tablet press run, operators must learn to distinguish between machine-related issues and granulation-related issues.

Optimal Tablet Press Operation: Machine versus Granulation

Fred A. Rowley is a senior pharmaceutical consultant with Dorado International, 152 Wilkerson Dr., Westminster, SC 29693, tel. 800.272.8191, fax 864.647.1155.

Tablet manufacturers often overlook critical basic concepts or established practices. The author draws from his own experiences and discusses how solid dosage manufacturers can improve production and product quality by optimizing major unit operations.

From the Formulator to the Tablet Manufacturing Floor: Desiderata and Troubleshooting

Madhusudan Hariharan is a senior research investigaor at the Pharmaeutical Sciences Solids Formulation Developmetn group of Pharmacia Corporation, Skokie, IL 60077, tel. 847.982.8984, fax 847.982.4900.

The authors modified a three-layer press to operate a compression-coated tablet process that may offer several advantages over tradditional compression coating operations.

A Novel Compression-Coated Tablet Dosage Form

Antonio Moroni, PhD, is the manager of pharmaceutical research at International Specialty Products, 1361 Alps Rd., Wayne, NJ 07040, tel. 973.628.3346, fax 973.628.3759.

The author assesses the compressibility of Plasdone S- 630 copovidone-based tablet formulations using roller-compaction and direct-compression processes.

A Novel Copovidone Binder for Dry Granulation and Direct-Compression Tableting

Gbenga Alebiowu, PhD, is a senior lecturer at the department of pharmaceutics, Obafemi Awolowo University, Ile-Ife, Nigeria.

O.A. Itiola is a professor in the Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, College of Medicine, University of Ibadan, Ibadan, Nigeria.

This comparative study suggests that pregelatinized starches are superior to natural starches in terms of improving the plastic deformation in tablet formulations during compression.

Effects of Natural and Pregelantinized Sorghum, Plantain, and Corn Starch Binders on the Compressional Characteristics of a Paracetamol Tablet Formulation

Charles R. Cunningham is a global technical manager at Colorcon, 415 Moyer Boulevard, West Point, PA 19486, tel. 215.699.7733, fax 215.661.2626.

Laura K. Scattergood is an applications technologist at Colorcon.

Bruce R. Kinsey is a global technical manager at Colorcon.

This study attempts to determine the combination of excipients found in commercial ASA products that would be suitable for use in an aqueous enteric film&#173coating process.

Formulation of Acetylsalicylic Acid Tablets for Aqueous Enteric Film Coating

Luca Dobetti is the R&D manager at Eurand International SpA, Site of Trieste, Via del Follatoio 12, I-34100 Trieste, Italy, tel. 39 040 899 2242, fax 39 040 899 2243.

Both academia and industry have been encouraged to generate quick&#173dissolving dosage forms as the demand for fast&#173disintegrating tablets and capsules has steadily increased.

Solid/Semi-Solid Dosage