Topic

Joanne Ratcliff, PhD, is communications project manager, Laboratory Weighing, Mettler Toledo GmbH, Joanne.Ratcliff@mt.com.

Articles

A program for calibration and routine testing of weighing instruments ensures accurate results.

Understanding Measurement Uncertainty in Weighing

Asking the right questions is crucial to establishing a biopharmaceutical facility design.

Designing a Biomanufacturing Facility Incorporating Single-Use Technologies

Regular removal of residues from disinfectants and sporicidals is important for improved aesthetics and safety in cleanrooms.

Best Practice: The Importance of Removing Sporicidal and Disinfectant Residue

Effective design of the tablet core and the coating process can help prevent film coating problems.

How To Prevent Tablet Coating Problems

Common defects in tablet film coating can be minimized by effective design of the tablet core and the coating process.

Preventing Film Coating Problems by Design

The revised USP Chapter  Sterile Product Packaging-Integrity Evaluation gives best practices for obtaining reliable data in container closure integrity testing and recommends quantitative deterministic methods rather than probabilistic methods.

Advancing Container Closure Integrity Testing

The revised USP Chapter 1207 gives best practices for obtaining reliable data in container closure integrity testing.

Using Deterministic Container Closure Integrity Testing

Jennifer Markarian is manufacturing reporter for Pharmaceutical Technology.

Analytical methods and functional assays are used to compare molecules and relate characteristics to quality attributes.

Determining Biosimilarity

Dynamic powder testing and measurement of bulk powder properties can complement shear cell testing to identify the causes of poor hopper performance in solid-dosage drug manufacturing.

Best Practices for Optimizing Hopper Performance

Problems in an induction-sealing process, such as untorqued or crooked caps, can be identified and corrected in real time using dynamic thermal imaging.

Troubleshooting