Drug Development

Patricia Van Arnum was executive editor of Pharmaceutical Technology.

Articles

The US and EU move forward with measures to fortify the pharmaceutical supply chain.

Strengthening the Supply Chain for Pharmaceutical Ingredients

Cynthia A. Challener is a contributing editor to Pharmaceutical Technology.

Cocrystals can enable the formulation of solid dosage drugs, but the FDA's final guidelines have left concerns about how their use could impact development timelines, the drug product manufacturing process, and the intellectual property position of products containing cocrystals.

Cocrystals Can Improve API Properties, But Will the Recent FDA Guidance Slow Adoption of This Technology?

Researchers at the Scripps Research Institute advance heteorcylic chemistry trhough new reagents and reaction-tracking techniques.

Elucidating Heterocyclic Chemistry in Pharmaceuticals

A recent study of computer-created and natural proteins suggests the number of sites where small-molecule drugs can bind to proteins is limited, thereby narrowing how to mitigate side effects through drug design.

Small-Molecule Drug Development: Recent Study Suggests Limited Binding Sites

Microwave spectroscopy overcomes some of the limitations of circular dichroism and vibrational circular dichroism in analyzing enantiomers.

Microwave Spectroscopy for Enantiomeric Detection of Chiral Molecules

Dynamic testing and advances in shear testing provide better insight into powder physical properties and external variables that affect powder behavior.

Multivariate Approaches for Powder Characterization

Access to extremely low and consistently controlled reaction temperatures can improve product yields and selectivities while also reducing costs.

Liquid Nitrogen Cooling Systems Advantageous for Low-Temperature Chemical Synthesis

The rejection by India's Supreme Court on Novartis' Glivec/Gleevec (imatinib mesylate) and other recent case law raise important issues on patent strategies for solid forms.

Intellectual Property Battles in Solid-State Chemistry

Solid-state chemistry is an important part of drug development, and public research is advancing the field.

Academic and Public Partnerships in Solid-State Chemistry

Cocrystals are used to improve the performance of APIs that have non-ideal physiochemical properties by cocrystallizing the API with a second compound that modulates the API to provide a way to improve a drug's bioavailability, stability, and processability.