Ingredients
Strengthening the Supply Chain for Pharmaceutical Ingredients
July 02, 2013
The US and EU move forward with measures to fortify the pharmaceutical supply chain.
Cocrystals Can Improve API Properties, But Will the Recent FDA Guidance Slow Adoption of This Technology?
June 26, 2013
Cocrystals can enable the formulation of solid dosage drugs, but the FDA's final guidelines have left concerns about how their use could impact development timelines, the drug product manufacturing process, and the intellectual property position of products containing cocrystals.
Elucidating Heterocyclic Chemistry in Pharmaceuticals
June 02, 2013
Researchers at the Scripps Research Institute advance heteorcylic chemistry trhough new reagents and reaction-tracking techniques.
Small-Molecule Drug Development: Recent Study Suggests Limited Binding Sites
June 02, 2013
A recent study of computer-created and natural proteins suggests the number of sites where small-molecule drugs can bind to proteins is limited, thereby narrowing how to mitigate side effects through drug design.
Microwave Spectroscopy for Enantiomeric Detection of Chiral Molecules
June 02, 2013
Microwave spectroscopy overcomes some of the limitations of circular dichroism and vibrational circular dichroism in analyzing enantiomers.
Multivariate Approaches for Powder Characterization
May 22, 2013
Dynamic testing and advances in shear testing provide better insight into powder physical properties and external variables that affect powder behavior.
Liquid Nitrogen Cooling Systems Advantageous for Low-Temperature Chemical Synthesis
May 16, 2013
Access to extremely low and consistently controlled reaction temperatures can improve product yields and selectivities while also reducing costs.
Intellectual Property Battles in Solid-State Chemistry
May 02, 2013
The rejection by India's Supreme Court on Novartis' Glivec/Gleevec (imatinib mesylate) and other recent case law raise important issues on patent strategies for solid forms.
Academic and Public Partnerships in Solid-State Chemistry
May 02, 2013
Solid-state chemistry is an important part of drug development, and public research is advancing the field.
Using Thermal Ink-Jet Printing Technology to Produce Pharmaceutical Cocrystals
May 02, 2013
Cocrystals are used to improve the performance of APIs that have non-ideal physiochemical properties by cocrystallizing the API with a second compound that modulates the API to provide a way to improve a drug's bioavailability, stability, and processability.